国际眼科纵览 ›› 2023, Vol. 47 ›› Issue (1): 74-78.doi: 10.3760/ cma.j.issn.1673-5803.2023.01.014

• 综述 • 上一篇    下一篇

阿柏西普治疗糖尿病性黄斑水肿的研究进展

祝颖星1,3 邹悦1,2 冯萧萧1,2 华启云1  肖丽波1,2 李云琴1,2   

  1. 1 云南大学附属医院 云南省第二人民医院 云南省眼科医院,昆明 650021;2 云南省眼科疾病临床医学中心,昆明 650021;3 昆明医科大学研究生院 650500
  • 收稿日期:2022-08-24 出版日期:2023-02-22 发布日期:2023-03-11
  • 通讯作者: 李云琴,Email: liyunqin2004@126.com E-mail:liyunqin2004@126.com
  • 基金资助:
    云南省眼病临床医学中心开放课题(YXZX-09;YXZX-10);云南省科技计划项目(202001AU070037)

Research progress of aflibercept in the treatment of diabetic macular edema

Zhu Yingxing1,3, Zou Yue1,2, Feng Xiaoxiao1,2, Hua Qiyun1, Xiao Libo1,2, Li Yunqin1,2   

  1. 1 Affiliated Hospital of Yunnan University, The Second People's Hospital of Yunnan Province,Yunnan Eye Hospital,Kunming 650021, China;2 Yunnan Eye Disease Clinical Medical Center,Kunming 650021, China; 3 Kunming Medical University Graduate School, Kunming 650500, China
  • Received:2022-08-24 Online:2023-02-22 Published:2023-03-11
  • Contact: Li Yunqin, Email: liyunqin2004@126.com E-mail:liyunqin2004@126.com
  • Supported by:
    Open Project of Yunnan Clinical Medical Center for Eye Diseases(YXZX-09; YXZX-10); Yunnan Science and Technology Project (202001AU070037)

摘要: 糖尿病性黄斑水肿(diabetic macular edema,DME)是导致糖尿病视网膜病变(diabetic retinopathy,DR)视力受损的主要原因。目前抗血管内皮生长因子(anti-vascular endothelial growth factor,anti-VEGF)药物作为治疗DME的一线用药,其中阿柏西普的优势在于亲和力强、作用靶点多、半衰期长等特点,研究表明,阿柏西普更适用于基线视力20/50或更差的DME患眼中,而更优化的给药方式仍在进一步探索中。(国际眼科纵览,2023, 47:74-78)

关键词: 糖尿病视网膜病变, 糖尿病性黄斑水肿, 抗血管内皮生长因子, 阿柏西普

Abstract: Diabetic macular edema (DME) is the main cause of visual impairment in diabetic retinopathy (DR). At present, anti-vascular endothelial growth factor (anti-VEGF) drugs, especially aflibercept, have been widely used in clinical practice as the first-line treatment for DME, and have achieved good results. The advantages of arbocept are strong affinity, multiple targets and long half-life, etc. Current studies have shown that arbocept is more suitable for DME patients with baseline visual acuity of 20/50 or worse, and a more optimized delivery mode is still under further exploration. (Int Rev Ophthalmol, 2022, 46: 74-78)

Key words: diabetic retinopathy, diabetic macular edema, anti-VEGF, aflibercept